From Hit to Lead


For the further development of the first hit compounds there are two possibilities:

1. The protein structure is not available: Synthesis of selected analogues of hit compounds will be carried out using medicinal chemistry strategies like bioisosteric exchange etc. derived from detailed analysis of structure activity relationships.

2. The protein structure is available: Suitable compounds derived from docking studies considering medicinal chemistry issues ("drug like properties") will be synthesised.

From Hit to Lead


Product Sheet: From Hit to Lead