Surface Plasmon Resonance (SPR) Analysis


SPR has become an important tool in drug discovery campaigns during the last few years. This powerful, label-free technique is used to measure the molecular interactions of small molecules with their biological targets like proteins and DNA. It provides detailed information on the binding affinity, association and dissociation kinetics of the interacting partner. Importantly, the interaction is monitored in real time (1, 2).
ElexoPharm has now added SPR analysis to its biochemistry portfolio. We can now evaluate your compounds in the corresponding target-relevant SPR assay.

Further information and prices are available on request. For this purpose, please contact Prof. Dr. Rolf Hartmann 

 

References

  1. Henn C, Boettcher S, Steinbach A, Hartmann RW (2012) Catalytic enzyme activity on a biosensor chip: combination of surface plasmon resonance and mass spectrometry. Anal Biochem. 428, 28-30.
  2. Klein T, Henn C, de Jong JC, Zimmer C, Kirsch B, Maurer CK, Pistorius D, M├╝ller R, Steinbach A, Hartmann RW (2012) Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: Biophysically guided hit discovery and optimization. ACS Chem Biol. 7, 1496-1501.